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KMID : 0379119990270020170
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Korean Journal of Mycology
1999 Volume.27 No. 2 p.170 ~ p.174
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Chemical Features and Purification of Immunostimulating Polysaccarides from the Fruit Bodies of Agaricus blazei
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김환묵/Kim, Hwan Mook
유익동/조수묵/박정식/김광포/Yoo, Ick Dong/Cho, Soo Muk/Park, Jung Sik/Kim, Kwang Po
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Abstract
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Water-soluble polysaccharides from the fruiting bodies of Agaricus blazei Murill were extracted with 0.9% sodium chloride and hot water, successively. The purified polysaccharides showed a potent immunostimulating activity. Eight major polysaccharides, which were named from AG-1 to AG-8, were fractionated and purified by ethanol precipitation, ion exchange chromatography on DEAE-cellulose and gel filtration on Toyopearl HW 65F. These polysaccharides were identified to be homogeneous by analysis of HPLC. Three major active polysaccharides (AG-2, -3, and -6) showed relatively strong immunostimulating activity. AG-2 and -3 were composed of glucose, galactose and mannose in the molar ratios of 74.0:15.3:10.7 and 63.6:17.6:12.7, respectively. AG-6 was composed of glucose and ribose in the molar ratios of 81.4:12.6.
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